With great interest we read the article by Wu et al on time spent outdoors and myopia. After just 1 year, the results of that prospective, interventional study, in which intervention consisted in encouraging schoolchildren to go outside the classroom …
Category: Peer-reviewed
Clinical Pharmacokinetics of Intra-arterial Melphalan and Topotecan Combination in Patients with Retinoblastoma – Corrected Proof
Purpose: To assess the antitumor activity, toxicity, and plasma pharmacokinetics of the combination of melphalan and topotecan for superselective ophthalmic artery infusion (SSOAI) treatment of children with retinoblastoma.Design: Single-center, prospective, clinical pharmacokinetic study.Participants: Twenty-six patients (27 eyes) with intraocular retinoblastoma.Methods: Patients with an indication for SSOAI received melphalan (3–6 mg) and topotecan (0.5–1 mg; doses calculated by age and weight). Plasma samples were obtained for pharmacokinetic studies, and a population approach via nonlinear mixed effects modeling was used. Safety and efficacy were assessed and compared with historical cohorts of patients treated with melphalan single-agent SSOAI.Main Outcome Measures: Melphalan and topotecan (Read more...)
Author reply – Corrected Proof
We thank Galvis et al for their letter. We also noted in our study that there are no differences in myopia progression when comparing myopic children with or without atropine treatment in both the intervention (recess outside classroom) and control gr…
Expert Panel Recommendations for the Use of Anti–Tumor Necrosis Factor Biologic Agents in Patients with Ocular Inflammatory Disorders – Corrected Proof
Purpose: To provide recommendations for the use of anti-tumor necrosis factor α (TNF-α) biologic agents in patients with ocular inflammatory disorders.Background: Ocular inflammatory diseases remain a leading cause of vision loss worldwide. Anti–TN…
The rod-driven a-wave of the dark-adapted mammalian electroretinogram
Publication date: Available online 16 December 2013 Source:Progress in Retinal and Eye Research Author(s): John G. Robson , Laura J. Frishman The a-wave of the electroretinogram (ERG) reflects the response of photoreceptors to light,…
Association between Visual Field Defects and Quality of Life in the United States – Corrected Proof
Purpose: To investigate the association between visual field defects and quality of life in the United States population.Design: Cross-sectional study.Participants: A total of 5186 participants in the 2005 through 2008 National Health and Nutrition Exa…
Effect of Centration and Circularity of Manual Capsulorrhexis on Cataract Surgery Refractive Outcomes – Corrected Proof
Purpose: To determine if postoperative refractive outcome in cataract surgery relates to centration or circularity of the capsulorrhexis.Design: Prospective, observational study.Participants: One hundred thirteen eyes from 108 patients undergoing routi…
Intravitreal Anti–Vascular Endothelial Growth Factor for Submacular Hemorrhage from Choroidal Neovascularization – Corrected Proof
Purpose: To evaluate the efficacy of intravitreal anti–vascular endothelial growth factor (VEGF) monotherapy for patients diagnosed with exudative age-related macular degeneration (AMD) accompanied by submacular hemorrhage.Design: Retrospective, observational case series.Participants: Ninety-one eyes of 91 patients who initially presented with submacular hemorrhage associated with exudative AMD from October 2009 to September 2012. Patients were followed up for at least 6 months after treatment.Methods: Best-corrected visual acuity (BCVA) was measured at diagnosis and at 1, 3, and 6 months after treatment. The duration of symptoms was estimated. The extent of hemorrhage was estimated using fundus photography, and central foveal thickness was measured (Read more...)
Factors Predictive of Remission of New-Onset Anterior Uveitis – Corrected Proof
Purpose: To identify factors predictive of remission of inflammation in new-onset anterior uveitis cases treated at tertiary uveitis care facilities.Design: Retrospective cohort study.Participants: Patients seeking treatment at participating academic u…
Ethnic Difference in Myopia between Asians and Non-Hispanic Whites in the United States – Corrected Proof
The excellent article by Wen et al supports what has been noted by ophthalmic epidemiologists, namely that myopia seems to much more prevalent in preschool children of Asian descendants (mainly Chinese) than non-Hispanic whites in the United States, w…
Distinct microRNA-155 expression in the vitreous of patients with primary vitreoretinal lymphoma and uveitis – Accepted Manuscript
Abstract: Purpose: To use micro- ribonucleic acid (microRNA) profiles in the vitreous for differential diagnosis of primary vitreoretinal lymphoma and uveitis. Design: A prospective cross-sectional study designMethods: This prospective cross-section st…
Choroidal neovascularization associated with focal choroidal excavation – Accepted Manuscript
Abstract: Purpose: To describe the clinical and imaging characteristics of choroidal neovascularization (CNV) accompanied by focal choroidal excavation.Design: Retrospective, interventional case series.Methods: The medical records of 16 patients (16 ey…
Relationship between Preferred Sleeping Position and Asymmetric Visual-field Loss in Open-angle Glaucoma Patients – Accepted Manuscript
Abstract: Purpose: To investigate the relationship between preferred sleeping position and asymmetric visual-field (VF) loss in open-angle glaucoma (OAG) patients.Design: Retrospective, cross-sectional study.Methods: Six hundred and ninety-two (692) pa…
Effect of scan quality on diagnostic accuracy of spectral domain optical coherence tomography in glaucoma – Accepted Manuscript
Abstract: Purpose: To evaluate the effect of scan quality on the diagnostic accuracies of optic nerve head (ONH), retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) parameters of spectral domain optical coherence tomography (SD-OCT) in glaucoma.Design: Cross-sectional study.Methods: 252 eyes of 183 control subjects (mean MD: -1.84 dB) and 207 eyes of 159 glaucoma patients (mean MD: -7.31 dB) underwent ONH, RNFL and GCC scanning with SD-OCT. Scan quality of SD-OCT images was based on signal strength index (SSI) values. Influence of SSI on diagnostic accuracy of SD-OCT was evaluated by receiver operating characteristic (ROC) regression.Results: Diagnostic accuracies (Read more...)
Effect of nepafenac eye drops on intraocular pressure – a randomized prospective study – Accepted Manuscript
Abstract: Purpose: To report the effect of nepafenac (0.1%) eye drops on intraocular pressure in eyes with cataract.Design: Prospective, randomized clinical trial.Methods: Three hundred and twenty-seven patients with bilateral cataracts in an institutional setting were included. All patients had a baseline intraocular pressure (IOP) ≤21 mmHg without a history of intraocular surgery in past 3 months. One eye of each individual was randomized to the treatment group with the other eye acting as a control. Nepafenac (0.1%) eye drops were instilled 3 times a day in the eye that received treatment. Intraocular pressure (IOP) with Goldmann applanation tonometer (GAT) was (Read more...)
Comparison of Hoffer Q and Haigis Formulae for Intraocular Lens Power Calculation according to the Anterior Chamber Depth in Short Eyes – Accepted Manuscript
Abstract: Purpose: To compare the accuracy of the Hoffer Q and Haigis formulae according to the anterior chamber depth (ACD) in cases of short axial length (AL).Design: Retrospective cross-sectional studyMethods: A total of 75 eyes from 75 patients with an AL of less than 22.0 mm implanted with an Acrysof IQ intraocular lens (IOL) were enrolled. The median absolute errors (MedAEs) predicted by the Hoffer Q and Haigis formulae were compared. The correlations between ACD and the predicted refractive error calculated using the two formulae were analyzed.Results: There were no significant differences in the MedAEs predicted by the Hoffer Q (Read more...)
Ocular phenotype analysis of a family with biallelic mutations in the BEST1 gene – Accepted Manuscript
Abstract: Purpose: To investigate the genetic cause and perform a comprehensive clinical analysis of a Danish family with autosomal recessive bestrophinopathy. To investigate whether Bestrophin may be expressed in normal human retina.Design: Retrospect…
Retinal Blood Vessel Positional Shifts and Glaucoma Progression – Corrected Proof
Purpose: To determine the characteristics and significance of retinal blood vessel (RBV) positional shifts over time in a cohort of patients with progressive glaucoma.Design: Retrospective cohort study.Participants: Baseline and serial stereophotographs from 1 eye of 125 patients with open-angle glaucoma with ≥8 reliable Swedish interactive threshold algorithm standard visual fields (VFs) were included. On the basis of global rates of threshold sensitivity change, patients with glaucoma were divided into groups of minimal (<−0.02 decibels [dB]/year), moderate (−0.02 to −0.65 dB/year), or fast (≥−0.65 dB/year) progression. To determine whether graders’ assessments of RBV positional shifts were false-positives, a control group consisting of (Read more...)
High Prevalence of Demodex brevis Infestation in Chalazia – Corrected Proof
Purpose: To investigate the correlation between demodicosis and chalazia in patients with the latter.Design: Prospective, observational, comparative study.Methods: Forty-four adult and 47 pediatric patients with chalazia and 34 adult and 30 pediatric age- and sex-matched patients without chalazia treated at an institutional referral eye center were included. All 155 patients underwent lash sampling followed by microscopic identification and counting of Demodex mites. All 91 patients with chalazia underwent surgical removal, and among them, 74 were followed up for 18 ± 4.3 months after surgery. Statistical correlation between ocular demodicosis and chalazia and its postoperative recurrence was performed.Results: Demodicosis was significantly more (Read more...)
Rotational Stability of a Single-Piece Toric Acrylic Intraocular Lens: A Pilot Study – Corrected Proof
Purpose: To evaluate the visual performance and rotational stability of the Tecnis Toric 1-piece intraocular lens (IOL) during the first 3 postoperative months.Design: Prospective, single-center study.Methods: In this study, patients with age-related c…