Category: Peer-reviewed

Clinical Pharmacokinetics of Intra-arterial Melphalan and Topotecan Combination in Patients with Retinoblastoma – Corrected Proof

Purpose: To assess the antitumor activity, toxicity, and plasma pharmacokinetics of the combination of melphalan and topotecan for superselective ophthalmic artery infusion (SSOAI) treatment of children with retinoblastoma.Design: Single-center, prospective, clinical pharmacokinetic study.Participants: Twenty-six patients (27 eyes) with intraocular retinoblastoma.Methods: Patients with an indication for SSOAI received melphalan (3–6 mg) and topotecan (0.5–1 mg; doses calculated by age and weight). Plasma samples were obtained for pharmacokinetic studies, and a population approach via nonlinear mixed effects modeling was used. Safety and efficacy were assessed and compared with historical cohorts of patients treated with melphalan single-agent SSOAI.Main Outcome Measures: Melphalan and topotecan (Read more...)

Author reply – Corrected Proof

We thank Galvis et al for their letter. We also noted in our study that there are no differences in myopia progression when comparing myopic children with or without atropine treatment in both the intervention (recess outside classroom) and control gr…

Intravitreal Anti–Vascular Endothelial Growth Factor for Submacular Hemorrhage from Choroidal Neovascularization – Corrected Proof

Purpose: To evaluate the efficacy of intravitreal anti–vascular endothelial growth factor (VEGF) monotherapy for patients diagnosed with exudative age-related macular degeneration (AMD) accompanied by submacular hemorrhage.Design: Retrospective, observational case series.Participants: Ninety-one eyes of 91 patients who initially presented with submacular hemorrhage associated with exudative AMD from October 2009 to September 2012. Patients were followed up for at least 6 months after treatment.Methods: Best-corrected visual acuity (BCVA) was measured at diagnosis and at 1, 3, and 6 months after treatment. The duration of symptoms was estimated. The extent of hemorrhage was estimated using fundus photography, and central foveal thickness was measured (Read more...)

Effect of scan quality on diagnostic accuracy of spectral domain optical coherence tomography in glaucoma – Accepted Manuscript

Abstract: Purpose: To evaluate the effect of scan quality on the diagnostic accuracies of optic nerve head (ONH), retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) parameters of spectral domain optical coherence tomography (SD-OCT) in glaucoma.Design: Cross-sectional study.Methods: 252 eyes of 183 control subjects (mean MD: -1.84 dB) and 207 eyes of 159 glaucoma patients (mean MD: -7.31 dB) underwent ONH, RNFL and GCC scanning with SD-OCT. Scan quality of SD-OCT images was based on signal strength index (SSI) values. Influence of SSI on diagnostic accuracy of SD-OCT was evaluated by receiver operating characteristic (ROC) regression.Results: Diagnostic accuracies (Read more...)

Effect of nepafenac eye drops on intraocular pressure – a randomized prospective study – Accepted Manuscript

Abstract: Purpose: To report the effect of nepafenac (0.1%) eye drops on intraocular pressure in eyes with cataract.Design: Prospective, randomized clinical trial.Methods: Three hundred and twenty-seven patients with bilateral cataracts in an institutional setting were included. All patients had a baseline intraocular pressure (IOP) ≤21 mmHg without a history of intraocular surgery in past 3 months. One eye of each individual was randomized to the treatment group with the other eye acting as a control. Nepafenac (0.1%) eye drops were instilled 3 times a day in the eye that received treatment. Intraocular pressure (IOP) with Goldmann applanation tonometer (GAT) was (Read more...)

Comparison of Hoffer Q and Haigis Formulae for Intraocular Lens Power Calculation according to the Anterior Chamber Depth in Short Eyes – Accepted Manuscript

Abstract: Purpose: To compare the accuracy of the Hoffer Q and Haigis formulae according to the anterior chamber depth (ACD) in cases of short axial length (AL).Design: Retrospective cross-sectional studyMethods: A total of 75 eyes from 75 patients with an AL of less than 22.0 mm implanted with an Acrysof IQ intraocular lens (IOL) were enrolled. The median absolute errors (MedAEs) predicted by the Hoffer Q and Haigis formulae were compared. The correlations between ACD and the predicted refractive error calculated using the two formulae were analyzed.Results: There were no significant differences in the MedAEs predicted by the Hoffer Q (Read more...)

Retinal Blood Vessel Positional Shifts and Glaucoma Progression – Corrected Proof

Purpose: To determine the characteristics and significance of retinal blood vessel (RBV) positional shifts over time in a cohort of patients with progressive glaucoma.Design: Retrospective cohort study.Participants: Baseline and serial stereophotographs from 1 eye of 125 patients with open-angle glaucoma with ≥8 reliable Swedish interactive threshold algorithm standard visual fields (VFs) were included. On the basis of global rates of threshold sensitivity change, patients with glaucoma were divided into groups of minimal (<−0.02 decibels [dB]/year), moderate (−0.02 to −0.65 dB/year), or fast (≥−0.65 dB/year) progression. To determine whether graders’ assessments of RBV positional shifts were false-positives, a control group consisting of (Read more...)

High Prevalence of Demodex brevis Infestation in Chalazia – Corrected Proof

Purpose: To investigate the correlation between demodicosis and chalazia in patients with the latter.Design: Prospective, observational, comparative study.Methods: Forty-four adult and 47 pediatric patients with chalazia and 34 adult and 30 pediatric age- and sex-matched patients without chalazia treated at an institutional referral eye center were included. All 155 patients underwent lash sampling followed by microscopic identification and counting of Demodex mites. All 91 patients with chalazia underwent surgical removal, and among them, 74 were followed up for 18 ± 4.3 months after surgery. Statistical correlation between ocular demodicosis and chalazia and its postoperative recurrence was performed.Results: Demodicosis was significantly more (Read more...)