Category: Peer-reviewed

Topical Rebamipide Treatment for Superior Limbic Keratoconjunctivitis in Patients with Thyroid Eye Disease – Accepted Manuscript

Abstract: Purpose: To evaluate efficacy of topical rebamipide for superior limbic keratoconjunctivitis (SLK) in patients with thyroid eye disease (TED).Design: A retrospective, observational case series.Methods: Thirty-three eyes from 20 TED patients with SLK who received topical rebamipide [Mucosta® ophthalmic suspension unit dose 2%; chemical name, (2RS)-2-(4-chlorobenzoylamino)-3-(2-oxo-1, 2-dihydroquinolin-4-yl) propanoic acid] were included. The following items were evaluated before and 4 weeks after the start of treatments: presence or absence of SLK, rose bengal staining score, AD classification (A, area; D, density) of fluorescein staining, Schirmer’s test I (without topical anesthesia), tear break-up time (TBUT), Hertel exophthalmometry values, and margin reflex distances-1 (Read more...)

Endophthalmitis Caused by Streptococcal Species: Clinical Settings, Microbiology, Management, and Outcomes – Accepted Manuscript

Abstract: Purpose: To report the clinical settings, antibiotic susceptibilities, and outcomes of endophthalmitis caused by Streptococcus species.Study Design: Retrospective, observational case series.Methods: Single-center study evaluating all patients with culture-positive endophthalmitis caused by Streptococcus species between January 1, 2000 and December 31, 2011.Results: Study criteria were met by 63 patients. The most common clinical settings were bleb-associated (17, 27%), post-intravitreal injection (16, 25%), and post-cataract surgery (13, 21%). The isolates were S. viridans (47, 71%), S. pneumoniae (13, 21%), and β-hemolytic Streptococci (5, 8%). Sixty (95%) of 63 isolates were susceptible to vancomycin, 47 (98%) of 48 to ceftriaxone (third generation (Read more...)

The 5-Year Incidence of Bleb-Related Infection and Its Risk Factors after Filtering Surgeries with Adjunctive Mitomycin C: Collaborative Bleb-Related Infection Incidence and Treatment Study 2 – Corrected Proof

Purpose: To report the 5-year incidence of bleb-related infection after mitomycin C–augmented glaucoma filtering surgery and to investigate the risk factors for infections.Design: Prospective, observational cohort study.Participants: A total of 1098 …

Gonioscopy-Assisted Transluminal Trabeculotomy, A Novel Ab Interno Trabeculotomy: Technique Report and Preliminary Results – Corrected Proof

Purpose: To introduce a novel, minimally invasive, ab interno approach to a circumferential 360-degree trabeculotomy and to report the preliminary results.Design: Retrospective, noncomparative cases series.Participants: Eighty-five eyes of 85 consecutive patients who sought treatment at Glaucoma Associates of Texas with uncontrolled open-angle glaucoma and underwent gonioscopy-assisted transluminal trabeculotomy (GATT) for whom there was at least 6 months of follow-up data.Methods: Retrospective chart review of patients who underwent GATT by 4 of the authors (D.S.G., D.G.G., O.S., R.L.F.) between October 2011 and October 2012. The surgery was performed in adults with various open-angle glaucomas.Main Outcome Measures: Intraocular pressure (IOP), glaucoma medications, (Read more...)

Clinical Measurement of the Angle of Ocular Movements in the Nine Cardinal Positions of Gaze – Corrected Proof

Purpose: To measure the maximum angle of ocular versions using photographs of the 9 cardinal positions and a modified limbus test.Design: An evaluation of diagnostic technology; a prospective observational study.Participants: We enrolled 104 healthy subjects, 20 to 40 years of age.Methods: Photographs were obtained in the 9 cardinal positions of gaze and the images were processed using Photoshop. The images were analyzed using the Image J program to measure the angle of version. The maximum angle of the 9 cardinal positions was quantified using a modified limbus test.Main Outcome Measures: We measured the maximum angle of ocular versions in the (Read more...)

Assessment of choroidal topographic changes by swept source optical coherence tomography after photodynamic therapy for central serous chorioretinopathy – Accepted Manuscript

Abstract: Purpose: To investigate the relationship between choroidal thickness and angiographic abnormalities in central serous chorioretinopathy (CSC) eyes by swept-source optical coherence tomography (Swept-OCT), before and after half-fluence photody…

Measurement of Scleral Thickness using Swept-Source Optical Coherence Tomography in Open-Angle Glaucoma Patients with Myopia – Accepted Manuscript

Abstract: Purpose: To use swept-source optical coherence tomography (OCT) to image the posterior sclera at the posterior pole and around the optic nerve head (ONH), and measure the subfoveal scleral thickness and laminar thickness to evaluate the relationship between the measured thicknesses and ocular parameters.Design: Prospective, cross-sectional design.Methods: One hundred and twelve glaucoma patients and 46 controls with axial length more than 26 mm were enrolled. Swept-source OCT images were obtained to capture the subfoveal and ONH region. Subfoveal scleral thickness and laminar thickness were measured from obtained B-scan images. To verify the reproducibility of the measurement, intraclass correlation coefficients (Read more...)

Dry Eye Exacerbation in Patients Exposed to Desiccating Stress under Controlled Environmental Conditions – Accepted Manuscript

Abstract: Purpose: To determine if controlled environmental conditions can induce acute exacerbations of signs and symptoms in dry eye and asymptomatic subjects.Design: Prospective cross-sectional study.Methods: Nineteen patients with dry eye and 20 asymptomatic controls were exposed to controlled low humidity (5% relative humidity, desiccating environment) for 2 hours in our Controlled Environmental Research Laboratory at the University of Valladolid. The patients completed the Single-Item Score Dry Eye Questionnaire and the following diagnostic tests were performed before and after exposure: tear osmolarity, phenol red thread test, conjunctival hyperemia, fluorescein tear-break-up time (T-BUT), Schirmer test, and ocular surface vital staining. Sixteen molecules (Read more...)