Dr Singh’s recent editorial entitled “Things Go Better with Cataract Surgery” points out that glaucoma care is unique in that there are inherent difficulties of measurement endpoints, inaccuracies of psychophysical testing, and confounding study va…
Category: Peer-reviewed
The Spectrum of Ocular Alterations in Patients with β-Thalassemia Syndromes Suggests a Pathology Similar to Pseudoxanthoma Elasticum – Corrected Proof
Purpose: To determine the prevalence and spectrum of ocular fundus abnormalities in patients with β-thalassemia and to investigate risk factors for their development.Design: Cross-sectional, observational study.Participants: A total of 255 patients with β-thalassemia major (TM) and β-thalassemia intermedia (TI) were consecutively recruited and investigated.Methods: Patients underwent best correct visual acuity, indirect ophthalmoscopy, and fundus photography, including fundus autofluorescence (FAF) and near-infrared reflectance imaging using a confocal scanning laser ophthalmoscope (cSLO). Hematologic parameters were determined, including mean ferritin levels, aspartate amino transferase, alanine amino transferase, calcium, pre-transfusion hemoglobin, history of splenectomy, and liver iron concentration. Factors associated with the ocular phenotype (Read more...)
The Ability of Healthy Volunteers to Simulate a Neurologic Field Defect on Automated Perimetry – Corrected Proof
Objective: To determine if volunteers can simulate and reproduce 3 types of neurologic field defects: hemianopia, quadrantanopia, and central scotoma.Design: Cross-sectional study.Participants: Thirty healthy volunteers new to perimetry (including auto…
Risk of Scar in the Comparison of Age-related Macular Degeneration Treatments Trials – Corrected Proof
Objective: To describe risk factors for scar in eyes treated with ranibizumab or bevacizumab for neovascular age-related macular degeneration (AMD).Design: Prospective cohort study within a randomized clinical trial.Participants: Patients with no scar on color fundus photography (CFP) or fluorescein angiography (FA) at enrollment in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT).Methods: Eyes were assigned to ranibizumab or bevacizumab treatment and to 1 of 3 dosing regimens for 2 years. Masked readers assessed CFP and FA. Baseline demographic characteristics, visual acuity, morphologic features on photography and optical coherence tomography (OCT), and genotypes associated with AMD risk were evaluated as (Read more...)
Associations between Health-Related Quality of Life and the Decision to Perform Surgery for Childhood Intermittent Exotropia – Corrected Proof
Objective: To assess associations between health-related quality of life (HRQOL) and the decision to perform strabismus surgery for children with intermittent exotropia.Design: Retrospective chart review.Participants: Children with intermittent exotropia.Methods: Included subjects, identified in a clinical practice, had assessment of HRQOL using the intermittent exotropia questionnaire (IXTQ), comprising child, proxy, and parent components (parent domains: function, psychosocial, and surgery). The IXTQ scores were evaluated for association with surgery, along with standard clinical measures: prism and alternate cover test (PACT), stereoacuity, and control score (mean of the 3 most recent scores). Included data were from preoperative examination (surgical cohort) or from most (Read more...)
Acetazolamide in Retinoschisis: A Prospective Study – Corrected Proof
X-linked retinoschisis (XLRS) is the leading cause of hereditary juvenile macular degeneration in males with an estimated prevalence ranging from 1 in 15 000 to 1 in 30 000. It accounts for approximately 5% of all childhood-onset inherited retinal …
Combination Therapy with Dexamethasone Intravitreal Implant and Macular Grid Laser in Patients with Branch Retinal Vein Occlusion – Accepted Manuscript
Abstract: Purpose: To test a combination of dexamethasone intravitreal implant with macular grid laser for macular edema in patients with branch retinal vein occlusion (BRVO).Design: Prospective interventional, randomized, multi-center studyMethods: Pa…
Combination Therapy with Diquafosol Tetrasodium and Sodium Hyaluronate in Patients with Dry Eye after Laser In Situ Keratomileusis – Accepted Manuscript
Abstract: Purpose: To evaluate the possible advantages of combination therapy with diquafosol tetrasodium and sodium hyaluronate for dry eye after laser in situ keratomileusis (LASIK).Design: Prospective, randomized, comparative trialMethods: A total o…
Defining 10-2 Visual Field Progression Criteria: Exploratory and Confirmatory Factor Analysis Using Pointwise Linear Regression – Corrected Proof
Purpose: To test different visual field progression criteria using trend analysis in a glaucoma population followed with long sequences of 10-2 tests as a first attempt to understand and document rates of progression in the central field.Design: Retrospective cohort study.Participants: We included 146 eyes of 146 patients with established glaucoma.Methods: Pointwise linear regression analysis using the methods of ordinary least squares was performed on the 68 test locations of the 10-2 visual field sequences. Threshold sensitivities at each test location were plotted as the dependent variable against follow-up time as the independent variable. Statistically significant progression or improvement of a (Read more...)
Author reply – Corrected Proof
We thank Tailor et al for their interest in our recent study describing cataract surgery in patients with nanophthalmos. They discuss the definition of nanophthalmos and microphthalmos. The most commonly used definition of nanophthalmos in recent stud…
Comparison of Outcomes from a Phase 3 Study of Age-Related Macular Degeneration with a Matched, Observational Cohort – Corrected Proof
Objective: To compare outcomes of intravitreal therapy from an observational study cohort with those of participants receiving treatment in the Minimally Classic/Occult Trial of the Anti-VEGF Antibody Ranibizumab (MARINA) for the treatment of neovascul…
Cataract Surgery in Patients with Nanophthalmos – Corrected Proof
We read with great interest the article by Steijns et al. They have reported visual outcomes and complications of cataract surgery in the largest case series of patients with nanophthalmos. We would like to highlight a major point related to the metho…
Appearance of Regressing Drusen on Adaptive Optics in Age-Related Macular Degeneration – Corrected Proof
In age-related macular degeneration, material between the basal lamina of the retinal pigment epithelium (RPE) and the inner collagenous layer of Bruch’s membrane are generally referred to as drusen. Although drusen “maturation” is characterized by…
Genetic Susceptibility, Dietary Antioxidants, and Long-term Incidence of Age-related Macular Degeneration in Two Populations – Corrected Proof
Objective: To examine effect modification between genetic susceptibility to age-related macular degeneration (AMD) and dietary antioxidant or fish consumption on AMD risk.Design: Pooled data analysis of population-based cohorts.Participants: Participants from the Blue Mountains Eye Study (BMES) and Rotterdam Study (RS).Methods: Dietary intakes of antioxidants (lutein/zeaxanthin [LZ], β-carotene, and vitamin C), long-chain omega-3 polyunsaturated fatty acids, and zinc were estimated from food frequency questionnaires. The AMD genetic risk was classified according to the number of risk alleles of CFH (rs1061170) or ARMS2 (rs10490924) as low (no or 1 risk allele) or high (≥2 risk alleles). Interactions between dietary intake and genetic (Read more...)
Retinal Blood Flow in Glaucomatous Eyes with Single-Hemifield Damage – Corrected Proof
Purpose: To examine the hypotheses that in glaucomatous eyes with single-hemifield damage, retinal blood flow (RBF) is significantly reduced in the retinal hemisphere corresponding with the abnormal visual hemifield and that there are significant associations among reduced retinal sensitivity (RS) in the abnormal hemifield, RBF, and structural measurements in the corresponding hemisphere.Design: Prospective, nonrandomized, case-control study.Participants: Thirty eyes of 30 patients with glaucoma with visual field loss confined to a single hemifield and 27 eyes of 27 controls.Methods: Normal and glaucomatous eyes underwent spectral-domain optical coherence tomography (SD-OCT) and standard automated perimetry. Doppler SD-OCT with a double-circle scanning pattern was (Read more...)
Driving Habits in Older Patients with Central Vision Loss – Corrected Proof
Objective: To determine if central visual loss is associated with driving cessation, driving restriction, or other-driver preference.Design: Cross-sectional study.Participants: Sixty-four subjects with bilateral visual loss (<20/32 in better eye) or severe unilateral visual loss (<20/200) from age-related macular degeneration (AMD) and 58 normally sighted controls between 60 and 80 years of age.Methods: Participants self-reported driving habits. Other-driver preference was defined as preferring that another drive when there is more than 1 driver in the car. Subjects reporting 2 or more driving limitations were considered to have restricted their driving.Main Outcome Measures: Self-reported driving cessation, other-driver preference, and driving restriction.Results: Age-related (Read more...)
Abnormal Deep Retinal Capillary Networking and Microaneurysms in the Outer Nuclear Layer of Diabetic Eyes – Corrected Proof
Diabetic retinopathy (DR) is the leading cause of legal blindness in several countries. In DR, breakdown of the inner blood–retinal barrier, with leakage of plasma from small blood vessels, is responsible for the swelling of central retina and develo…
Diagnostic Utility of Adipophilin Immunostain in Periocular Carcinomas – Corrected Proof
Purpose: To determine the efficacy of adipophilin immunohistochemistry in the diagnosis of sebaceous carcinoma of the ocular adnexal region and to provide the guidelines for interpretation of this immunostain.Design: Retrospective, histopathologic case series.Participants: A total of 25 patients with sebaceous carcinoma, 21 patients with basal cell carcinoma, 22 patients with conjunctival squamous cell carcinoma, 9 patients with cutaneous squamous cell carcinoma, and 5 patients with conjunctival mucoepidermoid carcinoma.Methods: Immunohistochemical staining for adipophilin was performed on paraffin-embedded tissues and correlated with hematoxylin–eosin, periodic acid–Schiff (PAS), and mucicarmine-stained preparations. Immunostaining was quantified by light microscopy and with a computerized image analysis system (Read more...)
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Fire Risk with Nasal Cannula Oxygen
Huddleston et al raise awareness of fire hazards with supplemental oxygen during ophthalmic plastic surgery and succinctly outline the variables that contribute to devastating operating room fires. We question the conclusion that “insisting on nasal…