Category: Peer-reviewed

Axial Biometry of the Entire Eye Using Ultra-Long Scan Depth Optical Coherence Tomography – Corrected Proof

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Purpose: To assess the repeatability of axial biometry of the entire eye using ultra-long scan depth optical coherence tomography (OCT) and to investigate the agreement with IOLMaster measurements (Carl Zeiss Meditec).Design: Prospective, observational case series.Methods: There were 37 adult subjects enrolled in group 1 and 12 adult subjects enrolled in group 2. Using ultra-long scan depth OCT, the left eyes of these groups were measured in 2 separate sessions. The images were processed by a manual method and custom-developed automatic software. A model eye was imaged for verification. The subjects in group 2 were imaged using ultra-long scan depth OCT (Read more...)

CABP4 Mutations Do Not Cause Congenital Stationary Night Blindness – Corrected Proof

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I read with interest the analysis of Dutch patients diagnosed with congenital stationary night blindness (CSNB) by Bijveld et al, particularly what was written regarding patients with recessive mutations in calcium binding protein 4 (CABP4; Mendelian Inheritance in Man *608965). CABP4 encodes a protein that is specifically located in photoreceptor synaptic terminals, where it probably modulates photoreceptor calcium release. Only 3 of 101 patients diagnosed with CSNB in the authors’ series had CABP4 mutations, and all 3 patients (2 families) harbored the same homozygous mutation (c.646C>T; p.Arg216X). These 3 patients had nystagmus and low vision. Two were photophobic. All 3 had (Read more...)

Incidence of Visual Improvement in Uveitis Cases with Visual Impairment Caused by Macular Edema – Corrected Proof

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Purpose: Among cases of visually significant uveitic macular edema (ME), to estimate the incidence of visual improvement and identify predictive factors.Design: Retrospective cohort study.Participants: Eyes with uveitis, seen at 5 academic ocular inflammation centers in the United States, for which ME was documented to be currently present and the principal cause of reduced visual acuity (<20/40).Methods: Data were obtained by standardized chart review.Main Outcome Measures: Decrease of ≥0.2 base 10 logarithm of visual acuity decimal fraction-equivalent; risk factors for such visual improvement.Results: We identified 1510 eyes (of 1077 patients) with visual impairment to a level <20/40 attributed to ME. Most (Read more...)

Androgen Receptor Identification in the Diagnosis of Eyelid Sebaceous Carcinomas – Accepted Manuscript

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Abstract: Purpose: To assess the role of androgen receptor detection in diagnosing eyelid sebaceous carcinomas and compare it with that of adipophilin.Design: Retrospective clinicopathologic study.Methods: Ten sebaceous carcinomas (eight invasive, two intraepithelial only) were immunohistochemically stained for androgen receptors and compared with adipophilin staining. Receptor staining was also performed on benign sebaceous tumors (a sebaceoma and an adenoma), and as controls on eyelid basal cell carcinomas, eyelid squamous cell carcinomas, conjunctival squamous dysplasias and conjunctival melanomas.Results: All eight patients with an invasive component of sebaceous carcinoma had a biopsy in which the tumor cells were diffusely androgen receptor positive (>20% (Read more...)

Incidence, Types, and Lifetime Risk of Adult-Onset Strabismus – Corrected Proof

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Objective: To describe the incidence and types of adult-onset strabismus in a geographically defined population.Design: Retrospectively reviewed population-based cohort.Participants: All adult (≥19 years of age) residents of Olmsted County, Minnesota, diagnosed with new-onset adult strabismus from January 1, 1985, through December 31, 2004.Methods: The medical records of all potential cases identified by the resources of the Rochester Epidemiology Project were reviewed.Main Outcome Measures: Incidence rates for adult-onset strabismus and its types.Results: Seven hundred fifty-three cases of new-onset adult strabismus were identified during the 20-year period, yielding an annual age- and gender-adjusted incidence rate of 54.1 cases (95% confidence interval, 50.2–58.0) per (Read more...)

RADIANCE: A Randomized Controlled Study of Ranibizumab in Patients with Choroidal Neovascularization Secondary to Pathologic Myopia – Corrected Proof

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Objective: To compare the efficacy and safety of ranibizumab 0.5 mg, guided by visual acuity (VA) stabilization or disease activity criteria, versus verteporfin photodynamic therapy (vPDT) in patients with visual impairment due to myopic choroidal neovascularization (CNV).Design: Phase III, 12-month, randomized, double-masked, multicenter, active-controlled study.Participants: Patients (N = 277) with visual impairment due to myopic CNV.Methods: Patients were randomized to receive ranibizumab on day 1, month 1, and thereafter as needed guided by VA stabilization criteria (group I, n = 106); ranibizumab on day 1 and thereafter as needed guided by disease activity criteria (group II, n = 116); or vPDT on day (Read more...)