Category: Peer-reviewed
The Phillips Thygeson Experiment in Trachoma
In the 1930s Phillips Thygeson and his associates were performing experiments to prove that the elementary bodies from the Halberstaedter-Prowazek inclusions were the infectious agent of trachoma. Using epithelium scraped from the eyes of infected chil…
Long-term Risk of Glaucoma After Congenital Cataract Surgery
We read with great interest the article published by Lambert and associates. They have highlighted a very important complication after pediatric cataract surgery. There are certain issues that need to be addressed. The authors enrolled 62 eyes of 37 pa…
Reply
We appreciate the interest of Carifi and associates in our recent article. They have raised some excellent points regarding the limitations of our study, some of which we acknowledged in the article. Since our study was retrospective and included patie…
Wills Eye Institute 5-Minute Ophthalmology Consult
Media Type: Textbook Target Audience: General ophthalmologists, ophthalmology residents and fellows
Ultrasound Biomicroscopy of the Ciliary Body in Ocular/Oculodermal Melanocytosis
We read with great interest and attention the recent article from Velazquez-Martin and associates regarding the evaluation of ciliary body thickness in eyes of patients with unilateral ocular/oculodermal melanocytosis. They concluded that ciliary body …
Reply
We appreciate the interest shown in our article. We agree that the Wilcoxon signed-rank test would be more appropriate. We have run the data using this test and have found that the results are statistically significantly consistent with the results usi…
Authors May Select Immediate Open Access to Their Articles
We all receive tabloids, mailings, and unsolicited or spam e-mails that intend to provide free information to either a large or sometimes a selective registered audience; some of this content has an advertising objective, but some content clearly has a…
Reply
We appreciate the interest of Galvis and associates in our study. We additionally applaud them for doing a surveillance of the local bacterial pathogens encountered in their geographic area. The authors point out the results of the ESCRS endophthalmiti…
Reply
We had proposed the short-term external buckling with pneumatic retinopexy as a novel and effective treatment for rhegmatogenous retinal detachment (RRD) with inferior retinal breaks, with a comparable success rate to other treatment methods.
The Effect of Prior Trabeculectomy on Refractive Outcomes of Cataract Surgery
We read with interest the recent article concerning the refractive outcomes after cataract surgery in patients who had a filtering bleb. We highlight that there is significant uncertainty in regard to refractive outcomes; despite intense research, we…
Axial Length in Eyes with Macular Hole
We read the recent article entitled “Choroidal Thickness in Both Eyes of Patients with Unilateral Idiopathic Macular Hole” by Zeng et al, and would like to offer our comments. The authors, in this cross-sectional study, demonstrated that choroid t…
Voriconazole for Fungal Keratitis
In their recently published trial, Sharma et al found topical voriconazole to be more effective than intrastromal voriconazole when added to topical natamycin in patients with recalcitrant fungal keratitis. This trial shares a similar protocol with se…
Long-term Safety of Ranibizumab in Neovascular Age-related Macular Degeneration
We read with interest the study from Silva et al on the long-term safety of ranibizumab 0.5 mg in neovascular age-related macular degeneration (nAMD). It described visual outcomes, drug tolerability, and safety of ranibizumab (Lucentis; Novartis Pharm…
Who’s on first?
“There are basically two kinds of people in this world. Those who accomplish something and those that claim to. The first group is less crowded.”—Mark Twain Eratosthenes, an ancient Greek mathematician, calculated the earth’s circumference in a…
Retinal Ganglion Cell Analysis in Leber’s Hereditary Optic Neuropathy
Leber’s hereditary optic neuropathy (LHON) is a rare, maternally inherited disorder that results in bilateral loss of central vision. Characteristic visual field defects in LHON consist of either central or cecocentral scotomas, with about 70% of the patients being young adult men. More than 90% of these patients carry 1 of 3 mitochondrial DNA (mtDNA) mutations, located at nucleotide positions 3460, 11778, or 14484, respectively, although >20 mtDNA point mutations have been reported in LHON patients worldwide. Retinal ganglion cells decrease by apoptosis, and finally the retinal nerve fiber thins in LHON. Recently, gene therapy has been considered likely to hold the most promise for the treatment of mitochondrial diseases, especially the hereditary optic neuropathies in which targeted therapy to the retinal ganglion cells is feasible. Although treatment options for these disorders are still in their infancy, prompt and exact diagnosis of LHON is important to help select the appropriate strategy.
This Issue At A Glance
Can ionizing radiation be used as an adjunctive treatment for neovascular age-related macular degeneration (AMD)? In the INTREPID study of low-voltage, external-beam, stereotactic radiotherapy (SRT), Jackson et al (p. 1893) found that SRT can signific…
Fluoroquinolones in Corneal Ulcers
We read with interest the article by Sharma et al on moxifloxacin 0.5% in treatment of corneal ulcers. Authors indicated that corneal scrapings were examined using the Gram stain and potassium hydroxide wet mount, and that any case showing fungal elem…
Toward First-line Molecular Diagnosis of Ocular Infectious Disease
Technology has driven the development of microbiology since its earliest days. Antonie van Leeuwenhoek first observed bacteria through the first microscope in the 1670s. However, it was more than 2 centuries before Robert Koch grew the first pure cult…
Cyclosporine A Drug-Delivery System for High-risk Keratoplasty
We read the article by Shi et al reporting the efficacy of a novel cyclosporine (CsA) drug delivery system (DDS) for suppressing the occurrence of rejection and improving the survival of corneal allografts after high-risk keratoplasty with great inter…