We read with great interest the innovative work of Shi et al on cyclosporine intraocular drug delivery system for high-risk keratoplasty. It is not true that endothelial graft rejection often occurs within 2 weeks after transplantation, as authors sta…
Category: Peer-reviewed
Author reply
We thank Prajna et al for their comments on our article titled, “Comparative evaluation of topical versus intrastromal voriconazole as an adjunct to natamycin in recalcitrant fungal keratitis.” At the time of our publication, 1 study had been publ…
Prevalence and Risk Factors for Developing Ophthalmic Manifestations in Pediatric Human Immunodeficiency Virus Infection
There are 3.4 million HIV-infected children worldwide and reports suggest that every hour about 30 children die as a result of AIDS. Although pediatric HIV infection in developing countries is on the rise, developed countries have noted a decline. Ocul…
Two Year SAVE Outcomes: 2.0 mg Ranibizumab for Recalcitrant Neovascular AMD
The Super-dose Anti-VEGF (SAVE) trial assessed the efficacy of 2.0 mg ranibizumab (0.05 ml), a 4-fold higher dose than the 0.5 mg dose approved by the US Food and Drug Administration, for the management of recalcitrant neovascular age-related macular d…
Other Considerations in Pterygium Surgery
The Ophthalmic Technology Assessment (OTA) is a valuable and timely assessment of the techniques that might be used for pterygium surgery and focusses attention on 2 aspects of pterygium surgery, namely recurrence rates and complications of the various…
Change in Prostaglandin Expression Levels and Synthesizing Activities
We read with great interest the recently published study by Shim et al, which the authors described as a cross-sectional, case-control, clinical trial. As a single study, such a design is not possible because cross-sectional, case-control, and clinica…
Editorial Board
Voriconazole for Fungal Keratitis
In their recently published trial, Sharma et al found topical voriconazole to be more effective than intrastromal voriconazole when added to topical natamycin in patients with recalcitrant fungal keratitis. This trial shares a similar protocol with se…
Axial Length in Eyes with Macular Hole
We read the recent article entitled “Choroidal Thickness in Both Eyes of Patients with Unilateral Idiopathic Macular Hole” by Zeng et al, and would like to offer our comments. The authors, in this cross-sectional study, demonstrated that choroid t…
Long-term Safety of Ranibizumab in Neovascular Age-related Macular Degeneration
We read with interest the study from Silva et al on the long-term safety of ranibizumab 0.5 mg in neovascular age-related macular degeneration (nAMD). It described visual outcomes, drug tolerability, and safety of ranibizumab (Lucentis; Novartis Pharm…
Who’s on first?
“There are basically two kinds of people in this world. Those who accomplish something and those that claim to. The first group is less crowded.”—Mark Twain Eratosthenes, an ancient Greek mathematician, calculated the earth’s circumference in a…
Retinal Ganglion Cell Analysis in Leber’s Hereditary Optic Neuropathy
Leber’s hereditary optic neuropathy (LHON) is a rare, maternally inherited disorder that results in bilateral loss of central vision. Characteristic visual field defects in LHON consist of either central or cecocentral scotomas, with about 70% of the patients being young adult men. More than 90% of these patients carry 1 of 3 mitochondrial DNA (mtDNA) mutations, located at nucleotide positions 3460, 11778, or 14484, respectively, although >20 mtDNA point mutations have been reported in LHON patients worldwide. Retinal ganglion cells decrease by apoptosis, and finally the retinal nerve fiber thins in LHON. Recently, gene therapy has been considered likely to hold the most promise for the treatment of mitochondrial diseases, especially the hereditary optic neuropathies in which targeted therapy to the retinal ganglion cells is feasible. Although treatment options for these disorders are still in their infancy, prompt and exact diagnosis of LHON is important to help select the appropriate strategy.
This Issue At A Glance
Can ionizing radiation be used as an adjunctive treatment for neovascular age-related macular degeneration (AMD)? In the INTREPID study of low-voltage, external-beam, stereotactic radiotherapy (SRT), Jackson et al (p. 1893) found that SRT can signific…
Fluoroquinolones in Corneal Ulcers
We read with interest the article by Sharma et al on moxifloxacin 0.5% in treatment of corneal ulcers. Authors indicated that corneal scrapings were examined using the Gram stain and potassium hydroxide wet mount, and that any case showing fungal elem…
Toward First-line Molecular Diagnosis of Ocular Infectious Disease
Technology has driven the development of microbiology since its earliest days. Antonie van Leeuwenhoek first observed bacteria through the first microscope in the 1670s. However, it was more than 2 centuries before Robert Koch grew the first pure cult…
Cyclosporine A Drug-Delivery System for High-risk Keratoplasty
We read the article by Shi et al reporting the efficacy of a novel cyclosporine (CsA) drug delivery system (DDS) for suppressing the occurrence of rejection and improving the survival of corneal allografts after high-risk keratoplasty with great inter…
A Simple Vista en Este Número
¿Puede utilizarse la radiación ionizante como tratamiento adyuvante para la degeneración macular relacionada con la edad (AMD)? En el estudio INTREPID de radioterapia estereotáctica (SRT) de haz externo de bajo voltaje, Jackson y otros (p. 1893) de…
Author reply
We thank Matonti et al for their interest in our study (SECURE). Matonti et al mention in their letter that the mean BCVA decrease of 4.3 letters from baseline observed in the SECURE study may be owing to retinal nerve fiber layer (RNFL) decrease and…
Erratum
With apologies from the publisher, in the Report entitled, “Adaptive optics imaging of idiopathic epiretinal membranes” which printed in the July 2013 issue (Ophthalmology 2013;120:1508-9), the affiliation Fondazione G.B. Bietti IRCCS, Rome, Italy …
Author reply
We would like to thank Galvis et al for their comments on our article. It has been demonstrated by us that the sensitivity of potassium hydroxide (KOH) in detecting fungal elements was 94.3%. This has also been substantiated by other authors who repor…