Category: Peer-reviewed

A Quantitative Method for Assessing the Degree of Axial Proptosis in Relation to Orbital Tissue Involvement in Graves’ Orbitopathy – Corrected Proof

by  •  • 0 Comments

Purpose:
To define a method of quantifying axial proptosis in patients with Graves’ orbitopathy (GO) and to validate a score that correlates with the orbital involvement and helps determine the degree of proptosis correction for elective orbital decompression.

Design:
Retrospective, case series.

Participants:
The study included 50 patients (group A) and 29 control subjects who underwent orbital computed tomography (CT). The method was then validated in another group of 21 patients with GO (group B).

Methods:
The orbital area (OA) was measured manually on the central axial section of the CT scan at a level where the lens is visualized. (Read more...)

Argon Laser Photoablation of Superficial Conjunctival Nevus: Results of a 3-Year Study – Corrected Proof

by  •  • 0 Comments

Purpose: To evaluate and report the results of a 3-year study investigating argon laser photoablation of superficial conjunctival nevus.Design: Retrospective, interventional case series.Methods: The medical charts of patients referred to our clinic for the removal of a conjunctival nevus were reviewed. Argon laser photoablation of superficial conjunctival nevi was performed for 230 patients during the period from March 2006 to February 2009. The clinical course, complications, and recurrence rates were evaluated.Results: The mean follow-up period was 71.29 ± 19.51 months (range, 36-100 months). The horizontal and vertical diameters of conjunctival nevi were 4.53 ± 1.85 mm and 3.41 ± 1.62 mm, respectively. Most nevi (Read more...)

Characterization of Microaneurysm Closure After Focal Laser Photocoagulation in Diabetic Macular Edema – Corrected Proof

by  •  • 0 Comments

Purpose: To characterize microaneurysm closure following focal laser photocoagulation in diabetic macular edema (DME) using simultaneous fluorescein angiography (FA) and spectral-domain optical coherence tomography (SD-OCT).Design: Retrospective observational case series.Methods: Leaking microaneurysms (n = 123) were analyzed in eyes (n = 29) with nonproliferative diabetic retinopathy (NPDR) that underwent navigated focal laser photocoagulation in DME and were followed at 3, 6, and 12 months. Closure of diabetic microaneurysms was characterized in detail following focal laser using SD-OCT.Results: Closure rate of microaneurysms by both FA and SD-OCT was 69.9% (84/123), 79.7% (98/123), and 82.9% (102/123) at 3, 6, and 12 months, respectively. Microaneurysm closure rate increased (Read more...)

Long-term Results After Transconjunctival Resuturing of the Scleral Flap in Hypotony Following Trabeculectomy – Corrected Proof

by  •  • 0 Comments

Purpose: To present the 4-year follow-up results in the surgical treatment of hypotony following trabeculectomy with mitomycin C in glaucoma patients with additional flap sutures.Design: Retrospective interventional case series.Methods: Since 2006, 53 patients with hypotony maculopathy attributable to overfiltration following glaucoma surgery (trabeculectomy with mitomycin C) were included in this institutional study. We were able to follow up intraocular pressure (IOP) and distance-corrected visual acuity in 33 (62%) over 4 years, whereas all were followed over 2 years. To elevate IOP, we placed tangential transconjunctival sutures through the scleral flap and connected them to the adjacent sclera in all 53 patients.Results: (Read more...)

Variants of Anterior Segment Dysgenesis and Cerebral Involvement in a Large Family With a Novel COL4A1 Mutation – Corrected Proof

by  •  • 0 Comments

Purpose: To investigate the diverse ocular manifestations and identify the causative mutation in a large family with autosomal dominant anterior segment dysgenesis accompanied in some individuals by cerebral vascular disease.Design: Retrospective observational case series and laboratory investigation.Methods: Forty-five family members from 4 generations underwent ophthalmic examination. Molecular genetic investigation included analysis with single nucleotide polymorphism (SNP) markers and DNA sequencing. Whole exome sequencing was performed in 1 individual.Results: A broad range of ocular manifestations was observed. Typical cases presented with corneal clouding, anterior synechiae, and iris hypoplasia. Posterior embryotoxon, corectopia, and early cataract development were also seen. One obligate carrier (Read more...)

Effect of Day Length on Eye Growth, Myopia Progression, and Change of Corneal Power in Myopic Children

by  •  • 0 Comments

Objective:
Because of the northern location of Denmark, the length of the day over the year varies from 7 to 17.5 hours. Experimental and clinical results suggest that the development of myopia may be related to ambient light exposure. The purpose of current study was to investigate whether axial eye growth, myopia progression, or corneal power change in Danish myopic children varies with the length of the day.

Design:
Cross-sectional study.

Participants:
Two hundred thirty-five children 8 to 14 years of age found to have myopia during screening for a (Read more...)